Multiparametric Magnetic Resonance Imaging in Determining Prognostic Factors for Cervical Cancer IB2-IIB Stages after Neoadjuvant Chemotherapy

Background : Comprehensive treatment of locally advanced cervical cancer (CC) requires the use informative diagnostic methods to assess tumor size, extent and other factors that determine prognosis disease. Purpose Determination opportunities multiparametric magnetic resonance imaging (mpMRI) in visualization residual assessment main prognostic patients with stage IB2-IIB (FIGO) after neoadjuvant chemotherapy (NACT). Material Patients (n = 120) were prospectively enrolled study; they received NACT followed by surgical or chemoradiotherapy (CRT). underwent mpMRI before not later than 14 days 3rd course NACT. To mpMRI, MRI-data compared pathomorphological results. In comparative analysis included following factors: size (maximum diameter), depth stromal invasion (mm), presence parametrial invasion. Potential MRI-signs suggestive for lymphovascular (LVI) parametrium also assessed. Results Obtained about showed statistically significant correlation results study (p < 0.0001) — R 2 0.77 0.69, respectively. Difference value measuring maximum diameter was on average 2.52±6.76 mm. MRI sensitivity 71.4 %, specificity 95.1 accuracy 88.9 PVPR PVNR %. predictors significantly associated LVI identified: edema 0.001) dilatation vessels (> 3 mm) 0.015). According these developed a mathematical model, which predicts risk having surgery Conclusion Multiparametric is an effective technique assessing tumor, MpMRI makes it possible potential signs, cancer.